Oxidized coenzyme Q10 and reduced coenzyme Q10

May 09, 2022

Coenzyme Q10 is divided into two forms: ubiquinone and ubinol,

Panthenol = reduced coenzyme Q10, while panthenol = oxidized coenzyme Q10.

Both are coenzyme Q10. What's the difference? It is mainly divided into two aspects: one is the difference of bioavailability. Oxidized coenzyme Q10 needs physical conversion to be absorbed and utilized, while reduced coenzyme Q10 can be directly absorbed and utilized; The second is the difference of content in the body. The effective content of oxidized coenzyme Q10 accounts for about 5% in the body, while reduced coenzyme Q10 accounts for about 95% in the body.

Because coenzyme Q10 itself is a fat soluble substance, the overall absorption of panthenol and panthenone is not good. From the standard database CAS in the field of chemical substance information, we can find the relevant molecular data of panthenol and Panthenol. We can see that the molecular difference between them is not large, and both have the problem of poor stability. However, due to the greater polarity of panthenol, it is easier to form micelles with water molecules in the gastrointestinal tract, so as to improve the absorption rate in the small intestine.

Studies have shown that partially oxidized coenzyme Q10 can be transformed into reduced coenzyme Q10 after absorption into lymphatic vessels in the small intestine, which seems to indicate that the final result of panthenol and Panthenol supplementation is the same?? In fact, this transformation process will be affected by differences between individuals. In healthy or young people, the absorption of ubiquinone into the body requires the conversion of redox structure, and the conversion efficiency to ubiquinone is high.

When affected by adverse factors such as age, mental stress or disease, the conversion efficiency will be reduced, and the overall absorption will also be greatly reduced.

In addition to the above differences, it should be noted that panthenol products have higher stability. By adding antioxidants to soft shell capsules, oxidation caused by other factors can be reduced during storage to produce panthenol, resulting in better bioavailability and health results. On the contrary, in the production process of ubiquinone products, most manufacturers often do not add antioxidants, resulting in poor stability, degradation and / or transformation, resulting in quality problems such as the reduction of ubiquinone content.

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